This research was conducted because the scientific learning ability of sixth-grade students had not yet achieved satisfactory results and required an appropriate solution. Therefore, the purpose of this study was to enhance the scientific learning ability of sixth- grade students through the 7Es teaching and learning model at a primary school in Phnom Penh. The study employed a Pre-experimental Research Design over a period of 10 weeks with 23 students. The results showed that the mean post-test score (x̅ = 8.18; S.D = 1.47) was higher than the pre-test score (x̅ = 3.01; S.D = 1.59). Specifically, the mean score for answering questions increased from 1.23 to 3.21; observation ability from 0.27 to 0.89; explanation ability from 0.24 to 1.63; conclusion ability from 0.01 to 0.85; and problem-solving ability from 1.28 to 1.61. Statistical analysis confirmed that p = 0.000*** < .05, indicating that the 7Es model was effective in improving students’ scientific learning ability. Therefore, teachers are encouraged to apply this model, and future research may extend its application to other subjects. Key words: 7Es Instructional Model, Science Learning Ability, Primary Level Scientific Subject